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1996-02-27
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Document 0264
DOCN M9630264
TI Ig-secreting and interferon-gamma-producing cells in mice mucosally
immunized with influenza virus.
DT 9603
AU Novak M; Yamamoto M; Fujihashi K; Moldoveanu Z; Kiyono H; McGhee JR;
Mestecky J; Secretech Inc., Birmingham, AL, USA.
SO Adv Exp Med Biol. 1995;371B:1587-90. Unique Identifier : AIDSLINE
MED/96001799
AB 1. Oral immunization of mice with influenza virus type A/Udorn, induced
antigen-specific IgA antibodies in external secretions (e.g., saliva and
fecal extract). 2. Increased numbers of antigen-specific IgA
spot-forming cells (SFC) were seen in mononuclear cells isolated from
IgA-effector tissues (e.g., SG) of mice orally-immunized with influenza
virus. 3. Following oral or systemic immunization of mice, IFN
gamma-secreting cells (Th1 type) displayed a characteristic pattern of
distribution which was related to the route of immunization.
DE Administration, Oral Animal Antibodies, Viral/BIOSYNTHESIS/BLOOD
Antibody-Producing Cells/*IMMUNOLOGY Antigens, Viral/ADMINISTRATION &
DOSAGE B-Lymphocytes/IMMUNOLOGY IgA/BLOOD IgA, Secretory/BIOSYNTHESIS
IgG/BIOSYNTHESIS/BLOOD *Immunity, Mucosal Immunization Injections,
Subcutaneous Interferon Type II/*BIOSYNTHESIS Mice Mice, Inbred BALB
C Orthomyxoviruses Type A/*IMMUNOLOGY Th1 Cells/IMMUNOLOGY JOURNAL
ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).